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Kwesi began his career in the youth set up at Ebbsfleet United before earning a move to Peterborough United in 2008. After two seasons with the Posh, including loan spells with Weymouth, King’s Lynn Town and Kettering Town, Kwesi departed London Road in 2010 returning to Non-League to sign for Thurrock. Just a season later in July 2011, Appiah signed for Margate, where he would enjoy the most prolific spell of his career. Kwesi’s impressive start to life at Margate, scoring 22 goals in 24 appearances, quickly caught the attention of sides much further up the pyramid and in January 2012 Crystal Palace won the race to his signature.
Across a five-year spell with Crystal Palace, Kwesi would enjoy loans spells away from Selhurst Park with the likes of Aldershot Town, Yeovil Town, Cambridge United, Notts County, AFC Wimbledon, Reading and Viking FK of Norway, however in the summer of 2017 following the expiration of his contract, Appiah would join one of his former loan clubs, AFC Wimbledon, on a permanent basis.
Kwesi would spend three seasons with the Dons, scoring 15 goals in 71 total appearances, but a move abroad was next on the cards for Appiah, signing for Northeast United in the Indian Super League in October 2020. Less than a year later, Kwesi returned to England, signing for League Two Crawley Town in August 2021. Following the mutual termination of his contract at the Broadfield Stadium in the summer of 2023, Kwesi would put pen to paper on a two-year contract with Boreham Wood in July 2023.
Kwesi also boasts seven senior appearances and two goals for Ghana, including scoring in the 2015 African Cup of Nations quarter final 3-0 win over Guinea. Despite losing on 9-8 penalties to the Ivory Coast, Kwesi started for the Black Stars in the AFCON final.
